Authors: Raúl Martínez-Fernández, M.D., Ph.D., Jorge U. Máñez-Miró, M.D., Rafael Rodríguez-Rojas, Ph.D., Marta del Álamo, M.D., Binit B. Shah, M.D., Frida Hernández-Fernández, M.Sc., José A. Pineda-Pardo, Ph.D., Mariana H.G. Monje, M.D., Ph.D., Beatriz Fernández-Rodríguez, M.D., Scott A. Sperling, Psy.D., David Mata-Marín, M.Sc., Pasqualina Guida, M.Sc., et al.
Published In: The New England Journal of Medicine Dec 2020; 383:2501-2513
We randomly assigned, in a 2:1 ratio, patients with markedly asymmetric Parkinson’s disease who had motor signs not fully controlled by medication or who were ineligible for deep-brain stimulation surgery to undergo focused ultrasound subthalamotomy on the side opposite their main motor signs or a sham procedure.
This randomized, sham-controlled trial showed that focused ultrasound subthalamotomy performed in one hemisphere improved the motor features of Parkinson’s disease on the more affected side at 4 months.